IGF1LR3 Igtrope 1500mcg, 1,5mg


IGF1LR3 is a modified version of insulin-like growth factor-1. The full name of the peptide is insulin-like growth factor-1 long arginine 3. … This results in IGF1-LR3 remaining in the bloodstream 120 times longer than IGF-1. IGF1-LR3 gains its prolonged half-life as a result of its structural changes.

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IGF1LR3 is a peptide consisting of 70 amino acids with a molecular weight of 7649 Da. IGF-1 has an A and B chain connected by disulfide bonds, like insulin, which is how it gets its name. The structural similarity to insulin explains the ability of IGF-1 to bind (with low affinity) to the insulin receptor. IGF-1 is secreted by many tissues and the secretory site seems to determine its actions. Most IGF-1 is secreted by the liver and is transported to other tissues, acting as an endocrine hormone. IGF-1 is also secreted by other tissues, including cartilaginous cells, and acts locally as a paracrine hormone.

Most of the IGF1LR3 produced by the liver is secreted for its proliferative and growth effects. Lower IGF-1 and growth hormone are often associated with excess body fat. IGF-1 and other proteins in the IGF family are growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue. IGF-1 plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is commercially available and is used for the treatment of growth failure. Therapeutic administration of IGF-1 is associated with reversing insulin sensitivity, reducing weight, and increasing metabolic expenditure as well as potential reversal of degeneration of spinal cord motor neuron axons in certain peripheral neuropathies.

IGF-1 LR3 has a modified amino acid sequence compared to biological IGF-1. It has an additional arginine at amino acid position 2. By making this change, it gives the molecule higher potency and a much longer half-life. For this reason, it is commonly used as a long-acting version for the same therapeutic reasons as the IGF-1.




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